the interdisciplinary approach, we assessed the role of the strategic factor in "leading reference groups in construction quality of life in the research area of districts 10 and 17 of tehran Municipality in 2020. using the Integrative theoretical approach and a simultaneous mixed method with the quantitative method 315 households with spatial cluster sampling method and then by G power sampling, selected and surveyed the statistical population research implementation qualitative methods interview, observation and focus group do dynamics research to describe and explain that how does the variance of the quality of life of the residents these neighborhoods and what is the role of reference groups in its construction.the research findings show that the priority of the residents of Hashemi neighborhood (region 10) choosing the reference groups, social and religious groups and Yaftabad neighborhood (region 17) economic and civil. average quality life these two neighborhoods is significantly different due to the difference between their reference groups. the residents research neighborhoods who chose reference group based contextual, biological communication variables, define and construct the mental and objective dimensions of their quality of life based patterns, criteria and judgments of their reference groups at the action level. The title of a sub-system in interaction with the urban management system in welfare planning at the structural level affect the quality of life of neighborhoods.